ABSTRACT
Uvaria chamae P.Beauv. belong to the Annonaceae family of flowering plants. It is distributed in the savannah and secondary forest. The plant is used in ethnomedicine for the treatment of malaria, inflammation, gonorrhea, dysentery; pile and fever. The ethyl alcohol leaves extract of the plant was subjected to phytochemical as well as antimalarial studies. Phytochemical studies were carried out using techniques including preliminary phytochemical tests, thin layer chromatographic analysis (TLC), column chromatography and gel filtration. The antimalarial activity of the crude ethyl alcohol leaves extract was evaluated using two models, suppressive and curative tests. The result of the preliminary phytochemical screening revealed the presence of saponins, flavonoids, carbohydrates, tannins, alkaloids and terpenoids. A flavonoids was isolated from the extract. The structure of the compound isolated was elucidated using UV, IR, 1D NMR and ESI-MS. The compound was found to be an epicatechin (3, 3, 4, 5, 7- pentahydroxyflavan). The leaf extract caused no lethality in mice at oral LD50 value of greater than 5000 mg/kg body weight. This indicated that the extract is safe for oral use. In the suppressive test the extract exhibited good antimalarial property that was dose dependent. At doses of 25, 50 and 100 mg/kgbody weight the extract produced a significant (P< 0.05) chemosuppression of 48, 53.3 and 65% respectively. Chloroquine the positive control drug produced the highest parasite chemosuppression at 79%. In the curative test the extract at doses of 25, 50 and 100 mg/kg body weight produced significant (P< 0.05) chemosuppression at 68, 70 and 73% respectively. Chloroquine the positive control drug produced the highest parasite chemosuppression of 98%. The result of this studies has established the rationale for the use of this plant in ethnomedicine. The isolated compound might be responsible for the observed biological activity
Background Of The Study
Security of library resources is very paramount in the provision of efficient l...
ABSTRACT
The consequences of drug related problems from Primary Healthcare facilities in Kano are so huge that there is need to address t...
Background of Study
The concept of traditional institution‖ has been the major phenomena in the recent...
Statement Of Research Problem
Packaging is a very important element in marketing the product especially...
Abstract
The study investigated the adoption of the use of smartphones among students of Kaduna Polytechnic and Nuhu Bamalli Polytechnic....
ABSTRACT
This study examined the problems of Solid Waste Management in Nigeria. To achieve this purpose...
ABSTRACT
The research work is carried out specifically to appreciate value Added Tax as an important source of revenue t...
Abstract
The most significant elements that enable us to understand economic growth and de...
ABSTRACT
The Human Immune deficiency Virus(HIV) and the Acquired Immune Deficiency Syndrome (AIDS) situation in Nigeria has affected bloo...
EXCERPT FROM THE STUDY
The goal of this study was to examine the effect of violent film on Nigerian female children in O...